The PARADIGM-HF study compared Entresto (sacubitril/valsartan) with enalapril in chronic heart failure patients with reduced ejection fraction (HFrEF). PARADIGM-HF demonstrated that Entresto was superior to enalapril in reducing the risks of cardiovascular death and first hospitalization for heart failure. The study was terminated early due to the significantly greater benefit of Entresto. PARADIGM-HF is hitherto the largest study involving heart failure patients.¹